Accelerating Innovations in Biomanufacturing Approaches through Collaboration Between NSF and the DOE BETO funded Agile BioFoundry

The National Science Foundation (NSF) and the Department of Energy’s Bioenergy Technologies Office (DOE BETO) recognize the critical roles that synthetic and engineering biology play in advancing the U.S. Bioeconomy. To translate advances in synthetic and engineering biology into products and processes that will impact the U.S. bioeconomy, there is a need to accelerate innovation and adopt new biomanufacturing approaches. The integrated Design-Build-Test-Learn (DBTL) capabilities of the DOE BETO funded Agile BioFoundry (ABF) offer a unique resource to the academic community to develop and implement innovative biodesign and biomanufacturing technologies and practices. To help advance the U.S. bioeconomy, these agencies invite proposals from researchers at institutions of higher education and non-profit organizations (eligible PIs). The proposals must leverage the unique DBTL capabilities available at the ABF to translate the latest advances in synthetic biology and engineering biology basic research into testable prototype processes and products that are potentially scalable and manufacturable and can be appropriately validated. Of particular interest are proposals that both leverage the DBTL capabilities of the ABF to translate basic science into bioeconomy-relevant innovation and also lead to the development of generalizable rules or theories of biological systems that enhance our understanding of basic science. In order to facilitate the utilization of the integrated DBTL capabilities available at the ABF and ensure the readiness of basic research projects for their translation to ABF platforms, NSF would support efforts of eligible PIs and their students, postdoctoral fellows, and other lab personnel on projects that can leverage the unique capabilities of the ABF. NSF support would be for all activity at the institution of higher education or non-profit organization that occurs in parallel to, or prior to, the work at ABF that readies the project for translation to practice. In order to increase collaboration across sectors and workforce development, NSF, through this program, can also support short term faculty fellows, post-doctoral fellows, graduate students or undergraduate student interns that are hosted by national laboratories or ABF. DOE BETO will cover the costs for implementation of approved projects at ABF. Partnering with industry is encouraged for technologies both to facilitate eventual scale up and regulatory approval. Investigators are advised to consult with ABF early in their proposal planning process. More information on the capabilities of the Agile BioFoundry can be found at https://agilebiofoundry.org/home/about/capabilities/. The required mechanism for collaboration with the Agile BioFoundry is to use the Agile BioFoundry Cooperative Research and Development Agreement (CRADA). For more information about the CRADA, including a template CRADA, please visit https://agilebiofoundry.org/work-with-us/.

NSF will coordinate and manage the review of proposals. Proposals will be shared with DOE BETO Technology Managers.

*Who May Submit Proposals: Proposals may only be submitted by the following: -Non-profit, non-academic organizations: Independent museums, observatories, research laboratories, professional societies and similar organizations located in the U.S. that are directly associated with educational or research activities. -Institutions of Higher Education (IHEs) - Two- and four-year IHEs (including community colleges) accredited in, and having a campus located in the US, acting on behalf of their faculty members.Special Instructions for International Branch Campuses of US IHEs: If the proposal includes funding to be provided to an international branch campus of a US institution of higher education (including through use of subawards and consultant arrangements), the proposer must explain the benefit(s) to the project of performance at the international branch campus, and justify why the project activities cannot be performed at the US campus.