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Development and Validation of Harmonized Methodologies to Measure NAD+ and Related Metabolites in Clinical Trials (U01 Clinical Trial Required)

National Institutes of Health

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Summary
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02 November 2023
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For profit
Not for profit (incl. NGOs)
Public sector
R&D and Higher Education
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Health, Justice and Social Welfare
Overview

This Notice of Funding Opportunity (NOFO) invites applications to develop and validate the standardized protocols for measuring nicotinamide adenine dinucleotide (NAD+) and related metabolites levels in humans, including sample collection and storage, assays calibration, and standardization of measurements across different types of samples such as plasma, tissue, or serum extracts, and validation of these protocols. Limited preclinical animal studies could be proposed by the applicants, if such studies are integral part of the applications and if they are needed to test the select elements of the standardized protocols in animal models before such protocols could be tested in humans. The proposed studies will be funded by individual awards, but the awardees will be required to interact as a network to exchange information, discuss their progress, pitfalls and issues arising during studies implementation.

Eligibility

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

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06 July 2023