Development and Characterization of Experimental models of post-TBI ADRD (R01 - Clinical Trial Not Allowed)

Goal is to have experimental models that can accurately reproduce neuropathological signatures and clinically relevant neurodegenerative, biochemical and behavioral sequelae as those seen in human subjects post-TBI AD/ADRDs. Requirement: Interdisciplinary Team science approach / consortium type of applications. Applications will include multiple sites (3-5 sites) developing and/or testing specific models that will then implement a test of reproducibility across the consortium. Requirement: Must have a clinician with expertise in post-TBI ADRD on the team. Encourage having neuropathologists as consultants on grants. Requirement: Models developed through this FOA will be required to share their model, model details and related standards with the VA-funded interagency preclinical resource center - PRECISE TBI Studies investigating neurodegeneration of white matter and chronic inflammation in post-TBI AD/ADRDs are highly encouraged. Innovative applications reaching beyond the current AD/ADRD models are highly encouraged.

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.