Enhancing Telehealth Strategies to Support Retention and Adherence to Antiretroviral Therapy (ART)

The purpose of this Notice of Funding Opportunity (NOFO) is to support the evaluation of the effectiveness of an enhanced telehealth program to improve adherence to HIV prevention and treatment medication, while also exploring the “implementability” of its practice into routine care. Specifically, the awardee will, via a hybrid effectiveness-implementation research design: 1) evaluate the effectiveness of an enhanced telehealth program for maintenance of HIV medication adherence among clinically stable people with HIV (PWH) and pre-exposure prophylaxis (PrEP) medication adherence for those at risk of HIV infection; and 2) identify potential implementation facilitators and challenges by evaluating the delivery of these strategies. Furthermore, the recipient will evaluate the cost and cost-effectiveness of providing telehealth to patients on antiretroviral therapy (ART) or PrEP, and evaluate program enhancements that will include, but may be not limited to, multi-month prescription refills, biospecimen sample self-collection, and the use of specialized staff such as community health workers and patient navigators. This enhanced telehealth program will focus on those disproportionately affected by HIV or at risk for HIV infection, including cis-gender Black or African American (hereafter referred to as Black) women with HIV, transgender women. and gay, bisexual and other men who have sex with men (hereafter referred to as MSM).

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