Assessing the Effectiveness of Programs, Policies, or Practices that Affect Social Determinants of Health to Promote Health Equity and Reduce Health…

The purpose of this NOFO is to support rapid, applied research with rigorous study design (i.e., natural experiments, quasi-experimental design studies, simulation modeling, and economic evaluations) to evaluate the impact of ongoing programs, policies, and environmental improvement strategies on SDOH and how these changes in SDOH improve chronic disease outcomes and related health disparities. The funded sites are expected to work together to create a network. This NOFO has three (3) components to achieve the purpose of the program: Component A (Research Studies to Assess Inequities in Addressing Chronic Diseases): The purpose is to support epidemiological research using studies with natural or quasi-experimental designs aimed at identifying and evaluating how inequities in chronic disease outcomes are mitigated by ongoing programs, policies, and environmental improvement strategies targeting SDOH. Component B (Studies to Assess Health and Economic Outcomes and Disparities of Chronic Diseases): The purpose is to support research that will apply a systems science approach to build simulation models of the interplay of SDOH factors and their relationship to chronic disease and health disparities, providing long-term estimates (e.g., 10-, 20-, 30-year) of chronic disease outcomes and disparities in quality-adjusted life-years, and the cost and cost-effectiveness of a policy, program, or strategy. Component C (Coordinating Center): The purpose is to support a coordinating center that provides organizational, logistic, and communication support to enhance the efficiency, productivity, and public health impact of the research centers that are funded under Components A and B. Applicants may apply for Component A or Component B. Applicants for Component C must apply for and be funded for Component A or Component B to be funded for Component C.

For an application to be considered, the application must be responsive to these Special Eligibility Requirements. If your application is incomplete or non-responsive to the special eligibility requirements listed in this section, it will not enter into the review process. Component A: Research Studies to Assess the Impact of Programs, Policies, or Practices that Address SDOH on Chronic Disease-Related Health Disparities 1. Applicants must have continuous access to data sets and/or data systems needed to accomplish study objectives and a minimum study sample size of 10,000 individuals for each priority area selected. 2. Applicants must have approval for unrestricted publication of the study findings, regardless of study outcomes. 3. Applicants may not request funding above the ceiling amount (direct and indirect) listed below: Tier 1: $600,000 Tier 2: $700,000 Tier 3: $800,000 Tier 4: $900,000 Tier 5: $1,000,000 Component B: SDOH Simulation Model Development Applicants must have access to the clinical and real-world data that are needed to develop and validate the simulation model. Applicants may not request funding above the ceiling amount of $1,000,000 (direct and indirect). Component C: Coordinating Center 1. Applicants for Component C must apply for Component A or Component B. 2. Applicants may not request funding above the ceiling amount of $500,000 (direct and indirect).